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Sildenafil is actually a potent and selective inhibitor of cGMP-specific phosphodiesterase style 5 (PDE5), that is to blame for degradation of cGMP within the corpus cavernosum. The molecular framework of sildenafil is similar to that of cGMP and acts to be a aggressive binding agent of PDE5 during the corpus cavernosum, causing far more cGMP and a
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